Necrotizing fasciitis, a rare and potentially lethal infection, is characterized by rapid and progressive involvement of the fascia and subcutaneous tissues. Here, we reported a 55-year-old woman with a history of recent surgery with complaints of erythema and foul-smelling discharge from the surgical incision site. The surgical incision site was opened, and cleaned with a sizable sterile normal saline, and the patient underwent ceftazidime, levofloxacin, metronidazole, and vancomycin. According to the results of microbiological cultures, non-albicans candida and its resistance to fluconazole, caspofungin, were substituted. However, necrotizing fasciitis increased. The rapid recognition, aggressive surgical intervention, and targeted antimicrobial therapy collectively played a pivotal role in successful recovery. The rapid recognition, aggressive surgical intervention, and targeted antimicrobial therapy collectively played a pivotal role in successful recovery. This case underscores the importance of vigilance in monitoring postoperative patients, particularly those with risk factors, and highlights the need for a multidisciplinary approach.